Increased noradrenaline efflux induced by local infusion of fluoxetine in the rat frontal cortex.

摘要: Abstract In microdialysis experiments in vivo, local infusion of either the selective serotonin reuptake inhibitor, fluoxetine, or noradrenaline uptake desipramine, increased efflux rat frontal cortex. Synaptosomal [3H]noradrenaline was used to test whether inhibition could contribute this effect fluoxetine. Low concentrations fluoxetine were less effective than desipramine at inhibiting uptake; both compounds more potent citalopram. To investigate involved an action on noradrenergic neurones, compared effects a lesion, induced by neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), and The lesion reduced presence citalopram but it desipramine. results suggest that actions non-noradrenergic mechanism is target for action.