Expression of insulin-like growth factor-II (IGF-II) and IGF-II/mannose-6-phosphate receptor in the rat hippocampus: an in situ hybridization and immunocytochemical study
作者： M E Couce , A J Weatherington , J F McGinty
DOI: 10.1210/ENDO.131.4.1396308
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摘要: After 3 or 4 weeks of age, insulin-like growth factor-II (IGF-II) gene expression in normal rats has been detected only mesenchymal tissue associated with the central nervous system. In contrast, IGF-II/mannose-6-phosphate receptor reported to be widely distributed adult rat brain. This study was performed order clarify cellular localization IGF-II and brain by comparing an immunocytochemical map distribution mRNAs situ hybridization. The highest levels mRNA were choroid plexus meningeal membranes. transcripts mainly present neuron-rich areas such as hippocampus, a lower signal meninges. Specific immunoreactivity neurons throughout forebrain, intensity pyramidal cell polymorphic layers hippocampus granule layer dentat...
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sci-hub.se 参考文章(37)
J. Hari, S. B. Pierce, D. O. Morgan, V. Sara, M. C. Smith, R. A. Roth, The receptor for insulin-like growth factor II mediates an insulin-like response. The EMBO Journal. ,vol. 6, pp. 3367- 3371 ,(1987) , 10.1002/J.1460-2075.1987.TB02658.X
Robert C. Baxter, Carolyn D. Scott, Insulin-Like Growth Factor-II Receptors Humana Press, Totowa, NJ. pp. 329- 346 ,(1990) , 10.1007/978-1-4612-0461-9_17
JF McGinty, D van der Kooy, FE Bloom, The distribution and morphology of opioid peptide immunoreactive neurons in the cerebral cortex of rats The Journal of Neuroscience. ,vol. 4, pp. 1104- 1117 ,(1984) , 10.1523/JNEUROSCI.04-04-01104.1984
S A Rogers, M R Hammerman, Mannose 6-phosphate potentiates insulin-like growth factor II-stimulated inositol trisphosphate production in proximal tubular basolateral membranes. Journal of Biological Chemistry. ,vol. 264, pp. 4273- 4276 ,(1989) , 10.1016/S0021-9258(18)83735-8
An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts. Journal of Biological Chemistry. ,vol. 262, pp. 12745- 12751 ,(1987) , 10.1016/S0021-9258(18)45269-6
T Okamoto, E Ogata, T Asano, T Iiri, T Katada, M Ui, J H Grubb, W S Sly, I Nishimoto, Y Murayama, Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate. Journal of Biological Chemistry. ,vol. 265, pp. 17456- 17462 ,(1990) , 10.1016/S0021-9258(18)38185-7
E Recio-Pinto, MM Rechler, DN Ishii, Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons The Journal of Neuroscience. ,vol. 6, pp. 1211- 1219 ,(1986) , 10.1523/JNEUROSCI.06-05-01211.1986
S. Gammeltoft, G.K. Haselbacher, R.E. Humbel, M. Fehlmann, E. Van Obberghen, Two types of receptor for insulin-like growth factors in mammalian brain. The EMBO Journal. ,vol. 4, pp. 3407- 3412 ,(1985) , 10.1002/J.1460-2075.1985.TB04097.X
G. A. Werther, M. Abate, A. Hogg, H. Cheesman, B. Oldfield, D. Hards, P. Hudson, B. Power, K. Freed, A. C. Herington, Localization of Insulin-Like Growth Factor-I mRNA in Rat Brain by in Situ Hybridization—Relationship to IGF-I Receptors Molecular Endocrinology. ,vol. 4, pp. 773- 778 ,(1990) , 10.1210/MEND-4-5-773
K. L. VALENTINO, I. OCRANT, R. G. ROSENFELD, Developmental expression of insulin-like growth factor-II receptor immunoreactivity in the rat central nervous system. Endocrinology. ,vol. 126, pp. 914- 920 ,(1990) , 10.1210/ENDO-126-2-914