Vascular density, protein and mRNA expression of hypoxia-inducible factor 2alpha, vascular endothelial growth factor and its type 2 receptor in the yolk sac membrane of three- and four-day-old chicken embryos incubated at 355 and 1378 metres above sea level

摘要: Vascular density of the yolk sac membrane (YSM), protein and mRNA expression hypoxia-inducible factor 2alpha (HIF-2α), vascular endothelial growth (VEGF-A) its type 2 receptor (FLK-1) in YSM were compared subjects incubated at two different altitudes: 355 1378 metres above sea level (masl) Colombia. On days 3 or 4 incubation, higher YSMs (p<0.05 both days), relative HIF-2α (p<0.01 p<0.001 4, respectively), VEGF-A respectively) FLK-1 (p<0.001 p<0.0001 day encountered embryos masl as to those masl. Information is presented about immunoexpression HIF-2α, endoderm, mesoderm ectoderm on it demonstrated that cells incubation express which had not been previously reported.