Omega-3 fatty acids have antidepressant activity in forced swimming test in Wistar rats.

摘要: Forced swimming test is used to induce a characteristic behavior of immobility in rats, which resem- bles depression humans some extent. We evaluated the effect omega-3 fatty acids alone as well com- pared it with standard antidepressant therapy fluoxetine both acute and chronic studies. In studies, rats were divided into 4 groups subjected following drug interventions n Group 1- control; 2- dose 10 mg/kg subcutaneously 23.5, 5 1 h before test; 3- 500 orally; 4- plus both. study, given single 2 prior while study daily for period 28 days. All animals 15-min pretest followed 24 later by 5-min test. A time sampling method was score behavioral activity each group. The results revealed that do not have any significant forced However, chron- ic affect significantly when compared control (p < 0.01) without on climbing efficacy combination more than changing behav- ioral It leads conclusion antide- pressant per se, has effi- cacy Wistar rats.