Non‐coding and coding genomic variants distinguish prostate cancer, castration‐resistant prostate cancer, familial prostate cancer, and metastatic castration‐resistant prostate cancer from each other
作者： Ibrahim O. Alanazi , Zafer S. Al Shehri , Esmaeil Ebrahimie , Hassan Giahi , Manijeh Mohammadi‐Dehcheshmeh
DOI: 10.1002/MC.22975
关键词:
摘要: A considerable number of deposited variants has provided new possibilities for knowledge discovery in different types prostate cancer. Here, we analyzed located on 3'UTR, 5'UTR, CDs, Intergenic, and Intronic regions castration-resistant cancer (8496 variants), familial (3241 metastatic (3693 (16599 variants). Chromosome 10p15-p14 2p13 were highly enriched (P < 0.00001) intergenic, intronic In contrast, 10p15-p14, 10q23.3, 12q13.11, 13q12.3, 1q25, 8p22 0.001) cancer, 11q22-q23, 14q21.1, 14q32.13 variant 0.001). 2 chromosome 1 hosted many regions. AKR1C3, BRCA1, BRCA2, CHGA, CYP19A1, HOXB13, KLK3, PTEN contained the highest variants. Network analysis showed that these genes are upstream important functions including gland development, tumor recurrence, cancer-specific survival, progression, mortality, long-term angiogenesis, AR. Interestingly, all EGFR, JAK2, NR3C1, PDZD2, SEMA3C had single nucleotide polymorphisms (SNP) consistent with high selection pressure during drug treatment consequent resistance. High occurrence 3'UTRs suggests importance regulatory cancer; an area been neglected compared coding This study provides a comprehensive overview genomic contributing to
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