Oxyhemoglobin dissociation curve as expo-exponential paradigm of asymmetric sigmoid function
作者： Dexter M. Easton
DOI: 10.1016/0022-5193(79)90316-3
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摘要: Abstract From the assumption that fractional increase of HbO2 as a function pO2 is proportional to HbO2, and proportionality coefficient relation decreases exponentially with pO2, an equation can be derived gives excellent fit full range oxyhemoglobin dissociation curve. To generate this asymmetric sigmoid curve, only one rate constant required. In addition, initial final conditions specify intermediate B, “shift factor” determines horizontal displacement The K specifies change specific respect O2. Governing slope temperature acidity increase, while B factor remains constant. For Hb in solution, decrease concentration, but appears unchanged. expo-exponential constants provide convenient specification course position
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