Über den mechanismus der katalase-wasserstoffperoxid-reaktion II. Die aktivitätszentren der katalase und ihre wirkungs-weise

摘要: Abstract 1. Besides the prosthetic groups, disulfide, sulfhydryl and basic groups in protein component of catalase are active centers for reaction with H 2 O . The disulfide behave as a redox system acting upon interact groups. This influences binding strength peroxide, which is combined Fe + group. It discussed could be responsible heme-protein interaction. 2. actual activity may derived from measured activity-pH relationship by elimination five intermediate equilibria. These are: dissociation hydroxide, pH dependence potential latent dependent because 3. With help these results fundamental mechanism catalatic explained. oxidation peroxide to oxygen bridges rate-determining process, being heme velocity depends size Values magnitude quantities presented