Vascular and Neuronal Development: Intersecting Parallelisms and rossroads

摘要: Two key events during evolution allowed vertebrates to develop specialized tissues able perform complex tasks: the formation of a highly branched vascular system ensuring that all receive adequate blood supply, and development nervous in which nerves branches transmit electrical signal peripheral organs. Both networks are laid down stereotyped manner, is tightly controlled by series shared developmental cues. Vessels use similar signals principles grow, differentiate navigate toward their final targets. Moreover, cross-talk and, when deregulated, they contribute medically relevant diseases. The emerging evidence both systems share several molecular pathways not only provides an important link between biology neuroscience, but also promises accelerate discovery new pathogenetic insights therapeutic strategies