The role of the Eph-ephrin signalling system in the regulation of developmental patterning.

摘要: The Eph and ephrin system, consisting of fourteen receptor tyrosine kinase proteins nine membrane in vertebrates, has been implicated the regulation many critical events during development. Binding cell surface results bi-directional signals, which regulate cytoskeletal, adhesive motile properties interacting cells. Through these signals are involved early embryonic movements, establish germ layers, movements formation tissue boundaries pathfinding axons. This review focuses on two vertebrate models, zebrafish mouse, experimental perturbation and/or expression vivo have provided important insights into role functioning Eph/ephrin system.