Effect of an increased dose of colchicine on microalbuminuria in children with Familial Mediterranean Fever

摘要: Abstract Aim of work Familial Mediterranean Fever (FMF) is an autosomal recessive condition causing recurrent attacks fever and polyserositis may result in amyloidosis the kidney. The aim present was to investigate response increased dose colchicine a group Egyptian children suffering from FMF albuminuria. Patients methods 40 patients with microalbuminuria were prospectively followed up Pediatric Rheumatology Outpatient Clinic Children’s Hospital, Cairo University, for period one year. All attack-free had no clinical evidence renal disease. Colchicine doses by 50%. Results Patients' mean age 9.8 ± 3.08 years (5–17 years), disease duration 3.96 ± 2.21 years (1–10 years) 15 males 25 females. 0.96 ± 0.46 mg/day 1.36 ± 0.46 mg/day during study period. new well tolerated most few minor complaints diarrhea affection liver functions. number annual decreased significantly colchicines 39.9 ± 22.43 attacks/year 7.92 ± 4.92 (p = 0.0001). Resolution occurred 50% within 3 months; another 30% responded 6 months, remaining 20% after 6th month treatment. There significant association between types mutations microalbuminuria. Conclusion Increased are effective treating should be given frequently recurring attacks. regularly screened