Expressão de uPAR na próstata canina normal e com lesões proliferativas
作者： Mariana Rodrigues Faleiro , Denise Caroline Toledo , Marcela M. Pinto Rodrigues , Renee Laufer Amorim , Luiz Augusto B. Brito
关键词:
摘要: Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested play a central role cell adhesion, angiogenesis, inflammation, tumor invasion. urokinase-type receptor (uPAR) is component of the PA, with range expression stromal cells. In this study, uPAR both normal prostates disorders (benign hyperplasia-BPH, atrophy-PIA, neoplasia-PIN, carcinoma-PC) was evaluated by immunohistochemistry tissue microarray (TMA) slide establish enzyme extracellular matrix (ECM) remodeling processes A total 298 cores 355 diagnoses were obtained, 36 (10.1%) prostates, 46 (13.0%) BPH, 128 (36.1%) PIA, 74 (20.8%) PIN 71 (20.0%) PC. There variation prostate according lesion, lower higher high neoplastic microenvironment indicates increased proteolytic activity PIN,
core.ac.uk
ufg.br
bvs-vet.org.br参考文章(39)
Renée Laufer Amorim, Marcela Marcondes Pinto Rodrigues, Giovana Wingeter di Santis, Veridiana Maria Brianezi Dignani de Moura, COX-2 and TGF-β expression in proliferative disorders of canine prostate Brazilian Journal of Veterinary Pathology. ,vol. 3, pp. 31- 36 ,(2010)
Charles Edo de Bock, Yao Wang, Clinical significance of urokinase‐type plasminogen activator receptor (uPAR) expression in cancer Medicinal Research Reviews. ,vol. 24, pp. 13- 39 ,(2004) , 10.1002/MED.10054
Angelo M De Marzo, Elizabeth A Platz, Jonathan I Epstein, Tehmina Ali, Anthanase Billis, Teresa Y Chan, Liang Cheng, Milton Datta, Lars Egevad, Dilek Ertoy-Baydar, Xavier Farre, Samson W Fine, Kenneth A Iczkowski, Michael Ittmann, Beatrice S Knudsen, Massimo Loda, Antonio Lopez-Beltran, Cristina Magi-Galluzzi, Gregor Mikuz, Roldolfo Montironi, Eli Pikarsky, Galina Pizov, Mark A Rubin, Hema Samaratunga, Thomas Sebo, Isabel A Sesterhenn, Rajal B Shah, Sabina Signoretti, Jeffery Simko, George Thomas, Patricia Troncoso, Toyonori T Tsuzuki, Geert J Van Leenders, Ximing J Yang, Ming Zhou, William D Figg, Ashraful Hoque, MS Lucia, None, A working group classification of focal prostate atrophy lesions. The American Journal of Surgical Pathology. ,vol. 30, pp. 1281- 1291 ,(2006) , 10.1097/01.PAS.0000213289.50660.BE
David J. Waters, David W. Hayden, Ford W. Bell, Jeffrey S. Klausner, Junqi Qian, David G. Bostwick, Prostatic intraepithelial neoplasia in dogs with spontaneous prostate cancer. The Prostate. ,vol. 30, pp. 92- 97 ,(1997) , 10.1002/(SICI)1097-0045(19970201)30:2<92::AID-PROS4>3.0.CO;2-M
Wanzhong Wang, Anders Bergh, Jan-Erik Damber, Morphological transition of proliferative inflammatory atrophy to high-grade intraepithelial neoplasia and cancer in human prostate The Prostate. ,vol. 69, pp. 1378- 1386 ,(2009) , 10.1002/PROS.20992
X-H Pei, Y Nakanishi, K Takayama, F Bai, N Hara, Granulocyte, granulocyte–macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells British Journal of Cancer. ,vol. 79, pp. 40- 46 ,(1999) , 10.1038/SJ.BJC.6690009
Andrew P Mazar, The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer Anti-Cancer Drugs. ,vol. 12, pp. 387- 400 ,(2001) , 10.1097/00001813-200106000-00001
RL Cohen, XP Xi, CW Crowley, BK Lucas, AD Levinson, MA Shuman, Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells. Blood. ,vol. 78, pp. 479- 487 ,(1991) , 10.1182/BLOOD.V78.2.479.479
Richard D. Estensen, Mildred Woodson, Akhouri A. Sinha, Holly Norris, Michael J. Wilson, Effects of aging and castration on plasminogen activator and metalloprotease activities in the rat prostate complex. Cellular and Molecular Biology Research. ,vol. 41, pp. 603- 612 ,(1995)
Rolando F. Del Maestro, Joseph F. Megyesi, Catherine L. Farrell, Mechanisms of tumor-associated edema: a review. Canadian Journal of Neurological Sciences. ,vol. 17, pp. 177- 183 ,(1990) , 10.1017/S0317167100030419