Clinical significance of urokinase‐type plasminogen activator receptor (uPAR) expression in cancer

摘要: The involvement of the urokinase-type plasminogen activator (uPA) system in particular has been extensively studied pathogenesis cancer. molecular role uPA receptor (uPAR) is well characterized with its participation cell migration and extracellular matrix (ECM) degradation. Over-expression uPAR cancer demonstrated many studies considered an attractive target for anticancer agents. We others have down-regulated expression attempt to inhibit metastasis based on role. Uniquely, which a glycosyl phosphatidylinositol anchored protein not only bound surface but also soluble form, suPAR. There now accumulated clinical experimental evidence supporting significant counterpart number solid cancers. can be associated tumor cells or stromal both. Differences observed using immunohistochemistry (IHC) are likely explained by use different antibodies techniques rather than true cellular differences reviewed here. This review summarizes relevance form prognosis diagnosis