Does lack of improvement in the first two weeks predict treatment resistance in recent-onset psychosis?

摘要: Randomized controlled trials among patients with schizophrenia have shown that <20% improvement in the first two weeks of treatment predicts nonresponse after 12 weeks. The findings been consistent for treated both conventional (1) and second-generation antipsychotic (AP) drugs (2). However, despite lack evidence regarding length time clinicians should pursue one regimen, most psychiatric textbooks practice guidelines suggest be at least four to six AP (3-5) before switching another (6). Large pragmatic chronic patients, such as Clinical Antipsychotic Trials Intervention Effectiveness (CATIE) (7), found no benefit from (8,9). No studies considered less recent-onset (i.e., than five years illness duration). We investigated responses APs strategies schizophrenia. We used IPAP algorithm, which is a well-defined algorithm treating (4,10).