Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
作者： Raphael A. Clynes , Terri L. Towers , Leonard G. Presta , Jeffrey V. Ravetch
DOI: 10.1038/74704
关键词:
摘要: … anti-tumor responses of D265A correlate with its impaired ability to activate Fc-receptor-bearing effector cells despite its ability to inhibit tumor … component of anti-tumor activity in vivo. …
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Daming Shan, Jeffrey A. Ledbetter, Oliver W. Press, Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies Blood. ,vol. 91, pp. 1644- 1652 ,(1998) , 10.1182/BLOOD.V91.5.1644
Michael S. Kopreski, Harold A. Harvey, Allan Lipton, Rakesh Kumar, Growth inhibition of breast cancer cell lines by combinations of anti-P185HER2 monoclonal antibody and cytokines. Anticancer Research. ,vol. 16, pp. 433- 436 ,(1996)
Hideo Masui, Ian Altas, John Mendelsohn, Zhen Fan, Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies Cancer Research. ,vol. 53, pp. 4322- 4328 ,(1993)
Silvia Bolland, Jeffrey V. Ravetch, Inhibitory pathways triggered by ITIM-containing receptors. Advances in Immunology. ,vol. 72, pp. 149- 177 ,(1999) , 10.1016/S0065-2776(08)60019-X
Hideo Masui, Takamasa Moroyama, John Mendelsohn, Mechanism of Antitumor Activity in Mice for Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies with Different Isotypes Cancer Research. ,vol. 46, pp. 5592- 5598 ,(1986)
J. Honeychurch, C. A. Penfold, A. L. Tutt, R. R. French, T. M. Illidge, M. J. Glennie, R. M E Parkhouse, G. G B Klaus, D. T. Fearon, H. M. McBride, Monoclonal antibody therapy of B cell lymphoma: signaling activity on tumor cells appears more important than recruitment of effectors. Journal of Immunology. ,vol. 161, pp. 3176- 3185 ,(1998)
R M Hudziak, G D Lewis, M Winget, B M Fendly, H M Shepard, A Ullrich, p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Molecular and Cellular Biology. ,vol. 9, pp. 1165- 1172 ,(1989) , 10.1128/MCB.9.3.1165
Joan Albanell, Larry Norton, Jose Baselga, Young Mee Kim, John Mendelsohn, Recombinant Humanized anti-HER2 Antibody (Herceptin) Enhances the Antitumor Activity of Paclitaxel and Doxorubicin Against HER2/neu Overexpressing Human Breast Cancer Xenografts Cancer Research. ,vol. 58, pp. 2825- 2831 ,(1998)
Jun Liu, Philip Lester, Stuart Builder, Steven J. Shire, Characterization of Complex Formation by Humanized Anti-IgE Monoclonal Antibody and Monoclonal Human IgE Biochemistry. ,vol. 34, pp. 10474- 10482 ,(1995) , 10.1021/BI00033A020
T.A. Waldmann, Lymphokine receptors: A target for immunotherapy of lymphomas Annals of Oncology. ,vol. 5, pp. 13- 17 ,(1994) , 10.1093/ANNONC/5.SUPPL_1.S13