Preclinical Modeling in Lymphoid Malignancies

摘要: Non-Hodgkin’s lymphoma (NHL) is one of the most common cancers in United States, accounting for about 4% all cancers. In spite aggressive chemotherapy and management, a majority patients relapse, making refractory NHL dreaded nightmares oncologists. Laboratory studies conducted on tumor cell lines, primary cells isolated from cancer patients, murine models contribute significantly to development therapeutics. The heterogeneity disease, limited availability biopsies, variability disease have necessitated animal evaluate potential drug therapies. Moreover, preclinical also help us understand pathogenesis role immune system lymphoma. As we enter into an era targeted therapeutics, these provide new platforms designing anti-lymphoma drugs. this chapter, summarize various lines including xenografts, syngeneic models, genetically engineered mice, humanized mice used study initiation growth lymphoma, microenvironment, efficacy Later discuss advantages disadvantages each model explain how them aid understanding interactions between tumors host environment.