Maternal Diet During Gestation and Lactation Modifies the Severity of Salt-Induced Hypertension and Renal Injury in Dahl Salt-Sensitive Rats

摘要: Environmental exposure of parents or early in life may affect disease development adults. We found that hypertension and renal injury induced by a high-salt diet were substantially attenuated Dahl SS/JrHsdMcwiCrl (SS/Crl) rats had been maintained for many generations on the grain-based 5L2F compared with SS/JrHsdMcwi (SS/Mcw) casein-based AIN-76A (mean arterial pressure, 116±9 versus 154±25 mm Hg; urinary albumin excretion, 23±12 170±80 mg/d). RNAseq analysis outer medulla identified 129 82 genes responding to uniquely SS/Mcw SS/Crl rats, respectively, along minor genetic differences between SS substrains. The salt strain included numerous homologs associated hypertension, cardiovascular disease, human. To narrow critical window exposure, we performed embryo-transfer experiments which single-cell embryos from 1 colony (SS/Mcw SS/Crl) transferred surrogate mothers other colony, their respective original diet. All offspring fed after weaning. Salt-induced exacerbated developed mothers. Conversely, salt-induced significantly Together, data suggest maternal during gestational-lactational period has substantial effects adult rats.