New Targetable Oncogenes in Non–Small-Cell Lung Cancer
作者： Geoffrey R. Oxnard , Adam Binder , Pasi A. Jänne
关键词:
摘要: The identification of oncogenic driver mutations underlying sensitivity to epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine inhibitors has led a surge interest in identifying additional targetable oncogenes non–small-cell lung cancer. A number new potentially gene alterations have been characterized recent years, including BRAF mutations, HER2 insertions, PIK3CA FGFR1 amplifications, DDR2 ROS1 rearrangements, RET rearrangements. In this review, we will discuss the techniques used discover each these candidate oncogenes, prevalence cancer, preclinical data supporting their role on small molecular development.
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