Prospective identification and characterization of breast cancer stem cells

摘要: A small percentage of cells within an established solid tumor have the properties stem cells. These give rise both to more and majority in that lost capacity for extensive proliferation ability new tumors. Thus, heterogeneity reflects presence cell progeny arising from a cell. We developed xenograft model which we been able establish tumors primary via injection mammary gland severely immunodeficient mice. assay allowed us do biological molecular assays characterize clonogenic also evidence strongly implicates Notch pathway, especially 4, as playing central pathway carcinogenesis. This discovery is basis compositions, methods distinguishing functionally different populations cells, using these studying effects therapeutic agents on growth, identifying testing novel anti-cancer therapies directed