Hedgehog signaling pathway antagonist cancer treatment
作者： Max Wicha , Gabriela Dontu , Suling Liu
DOI:
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摘要: The present invention provides methods and compositions for treating tumorigenic cells (e.g., mammary progenitor cancer cells), with hedgehog signaling pathway antagonists Cyclopamine or analogs thereof), as well screening their ability serve anti-neoplastic agents capable of killing cells. identifying based on increased expression a component (e.g. PTCHl, Dih, GUI, Bmi-1, VEGF), obtaining enriched populations cells, causing to proliferate and/or differentiate.
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