Airway responses to aerosolized methacholine and citric acid in ponies with recurrent airway obstruction (heaves).

摘要: We measured lung function and airway reactivity in response to methacholine citric acid administered by aerosol 2 groups of ponies (principal control). Principal had a history heaves, disease characterized recurrent obstruction. Control no respiratory disease. Both principal control were paired control), measurements made when clinical remission (Period A), following barn exposure acute obstruction B), 1 wk after they returned pasture (Periods C D). Differences between primarily found at Period B. Barn housing B) decreased dynamic compliance (Cdyn) increased pulmonary resistance (RL) but not ponies. When compared with B, demonstrated hyperreactivity. The dose required reduce Cdyn 65% baseline (ED65Cdyn) was lower, the change RL induced an 0.1 mg/ml (delta 0.1) higher, percent %Cdyn larger than A 10-min inhalation 10% did cause changes either group increase acid, whereas acid. conclude that from heaves are hyperreactive aerosols or Hyperreactivity only exists during exacerbations