Relationship of horse owner assessed respiratory signs index to characteristics of recurrent airway obstruction in two Warmblood families.

摘要: Summary Reasons for performing study: The horse owner assessed respiratory signs index (HOARSI-1–4, healthy, mildly, moderately and severely affected, respectively) is based on owner-reported clinical history has been used the investigation of recurrent airway obstruction (RAO) genetics utilising large sample sizes. Reliable phenotype identification paramount importance in genetic studies. Owner reports have shown good repeatability, but agreement HOARSI with an in-depth examination lower tract not investigated. Objectives: To determine correlation grades 3/4 characteristics RAO HOARSI-2 inflammatory disease. Further, to test whether there are phenotypic differences manifestation lung disease between families. Methods: Seventy-one direct offspring 2 RAO-affected Warmblood stallions (33 from first family, 38 second) were graded as HOARSI-1–4 underwent a system, arterial blood gas analysis, endoscopic mucus scoring, cytology tracheobronchial secretion (TBS) bronchoalveolar lavage fluid (BALF), assessment reactivity methacholine chloride. Results: HOARSI-3/4 animals exacerbation showed consistent RAO: coughing, nasal discharge, abnormal sounds breathing pattern well increased numbers neutrophils TBS BALF, excessive accumulation hyper-responsiveness methacholine. horses remission only had amounts tracheal neutrophil percentages. Clinical phenotypes significantly different families. Conclusions relevance: reliably identifies our population.