Mixed inheritance of equine recurrent airway obstruction.

摘要: BACKGROUND: Mode of inheritance equine recurrent airway obstruction (RAO) is unknown. HYPOTHESIS: Major genes are responsible for RAO. ANIMALS: Direct offspring 2 RAO-affected Warmblood stallions (n = 197; n 163) and a representative sample Swiss Warmbloods 401). METHODS: One environmental 4 genetic models (general, mixed inheritance, major gene, polygene) were tested Horse Owner Assessed Respiratory Signs Index (1-4, unaffected to severely affected) by segregation analyses the half-sib sire families, both combined separately, using prevalences estimated in sample. RESULTS: In all data sets model was most likely explain pattern inheritance. 3 datasets did not differ significantly from general (P= .62, P= 1.00, .27) but always better than gene (P < .01) polygene .01). The frequency deleterious allele differed considerably between families .23 .06). displacement large (t= 17.52 t= 12.24) heritability extremely (h(2)= 1). CONCLUSIONS AND CLINICAL RELEVANCE: Segregation clearly reveal presence playing role 1 family, mode autosomal dominant, whereas other family it recessive. Although expression RAO influenced exposure hay, these findings suggest strong, complex background