Cutting Edge: Genetic Variation Influences FcεRI-Induced Mast Cell Activation and Allergic Responses
作者： Yumi Yamashita , Nicolas Charles , Yasuko Furumoto , Sandra Odom , Toshiyuki Yamashita
DOI: 10.4049/JIMMUNOL.179.2.740
关键词:
摘要: Mast cell responses are influenced by a diverse array of environmental factors, but little is known about the effect genetic background. In this study, we report that 129/Sv mice had high levels circulating IgE, increased expression high-affinity receptor for IgE (FceRI), and greater sensitivity to anaphylaxis when compared with C57BL/6 mice. Bone marrow-derived mast cells (BMMCs) from showed more robust degranulation upon engagement FceRI. Deficiency Src family kinase Lyn enhanced in BMMCs inhibited response cells. lyn −/− reduced Fyn, increasing its markedly degranulation. human silencing or Fyn resulted hyperdegranulation hypodegranulation, respectively. The findings demonstrate influence on extent cell’s identify as contributory determinant.
jimmunol.org参考文章(19)
Valerie Hernandez-Hansen, Alexander J. Smith, Zurab Surviladze, Alexandre Chigaev, Tomas Mazel, Janet Kalesnikoff, Clifford A. Lowell, Gerald Krystal, Larry A. Sklar, Bridget S. Wilson, Janet M. Oliver, Dysregulated FcεRI Signaling and Altered Fyn and SHIP Activities in Lyn-Deficient Mast Cells Journal of Immunology. ,vol. 173, pp. 100- 112 ,(2004) , 10.4049/JIMMUNOL.173.1.100
Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M. Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, Carol Sawyer, Klaus Okkenhaug, Peter Finan, Bart Vanhaesebroeck, Essential role for the p110δ phosphoinositide 3-kinase in the allergic response Nature. ,vol. 431, pp. 1007- 1011 ,(2004) , 10.1038/NATURE02991
Howard R. Katz, Richard L. Stevens, K.Frank Austen, Heterogeneity of mammalian mast cells differentiated in vivo and in vitro The Journal of Allergy and Clinical Immunology. ,vol. 76, pp. 250- 259 ,(1985) , 10.1016/0091-6749(85)90638-4
Donata Vercelli, Genetics, epigenetics, and the environment: switching, buffering, releasing. The Journal of Allergy and Clinical Immunology. ,vol. 113, pp. 381- 386 ,(2004) , 10.1016/J.JACI.2004.01.752
Christine Tkaczyk, Michael A. Beaven, Saskia M. Brachman, Dean D. Metcalfe, Alasdair M. Gilfillan, The Phospholipase Cγ1-dependent Pathway of FcϵRI-mediated Mast Cell Activation Is Regulated Independently of Phosphatidylinositol 3-Kinase Journal of Biological Chemistry. ,vol. 278, pp. 48474- 48484 ,(2003) , 10.1074/JBC.M301350200
Jochen Wedemeyer, Mindy Tsai, Stephen J Galli, Roles of mast cells and basophils in innate and acquired immunity. Current Opinion in Immunology. ,vol. 12, pp. 624- 631 ,(2000) , 10.1016/S0952-7915(00)00154-0
Richard Pumphrey, Anaphylaxis: can we tell who is at risk of a fatal reaction? Current Opinion in Allergy and Clinical Immunology. ,vol. 4, pp. 285- 290 ,(2004) , 10.1097/01.ALL.0000136762.89313.0B
Shoko Iwaki, Christine Tkaczyk, Anne B. Satterthwaite, Kristina Halcomb, Michael A. Beaven, Dean D. Metcalfe, Alasdair M. Gilfillan, Btk Plays a Crucial Role in the Amplification of FcϵRI-mediated Mast Cell Activation by Kit Journal of Biological Chemistry. ,vol. 280, pp. 40261- 40270 ,(2005) , 10.1074/JBC.M506063200
Harmjan Kuipers, Bart N Lambrecht, The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma Current Opinion in Immunology. ,vol. 16, pp. 702- 708 ,(2004) , 10.1016/J.COI.2004.09.010
Sandra M. O'neill, Miriam T. Brady, John J. Callanan, Grace Mulcahy, Patrick Joyce, Kingston H.G. Mills, John P. Dalton, Fasciola hepatica infection downregulates Th1 responses in mice Parasite Immunology. ,vol. 22, pp. 147- 155 ,(2000) , 10.1046/J.1365-3024.2000.00290.X