The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses.
作者： J. Klukowska-Rötzler , J. E. Swinburne , C. Drögemüller , G. Dolf , J. Janda
DOI: 10.1111/J.1365-2052.2011.02277.X
关键词:
摘要: Recurrent airway obstruction (RAO) in horses is the result of an interaction genetic and environmental factors shares many characteristics with human asthma. Many studies have suggested that interleukin-4 receptor gene (IL4R) associated this disease, a QTL region on chromosome 13 containing IL4R was previously detected one two Swiss Warmblood families. We sequenced entire family 93 variants including five non-synonymous protein-coding variants. The allele distribution at these SNPs supported signal. Subsequently, we investigated mRNA expression bronchoalveolar lavage fluid cells. During exacerbation, increased RAO-affected offspring implicated family, but not other family. These findings support plays role some cases RAO.
sci-hub.se 参考文章(20)
E. LAUMEN, M. G. DOHERR, V. GERBER, Relationship of horse owner assessed respiratory signs index to characteristics of recurrent airway obstruction in two Warmblood families. Equine Veterinary Journal. ,vol. 42, pp. 142- 148 ,(2010) , 10.2746/042516409X479586
V. Gerber, D. Baleri, J. Klukowska-Rötzler, J.E. Swinburne, G. Dolf, Mixed inheritance of equine recurrent airway obstruction. Journal of Veterinary Internal Medicine. ,vol. 23, pp. 626- 630 ,(2009) , 10.1111/J.1939-1676.2009.0292.X
Naoko Hosomi, Kazuyoshi Fukai, Naoki Oiso, Atsushi Kato, Masamitsu Ishii, Hiroyuki Kunimoto, Koichi Nakajima, Polymorphisms in the Promoter of the Interleukin-4 Receptor α Chain Gene Are Associated with Atopic Dermatitis in Japan Journal of Investigative Dermatology. ,vol. 122, pp. 843- 845 ,(2004) , 10.1111/J.0022-202X.2004.22338.X
Alessandra Ramseyer, Vincent Gerber, Dominik Burger, Reto Straub, Cornel Boog, Eliane Marti, Claude Gaillard, Ursula Jost, Effects of genetic and environmental factors on chronic lower airway disease in horses. Journal of Veterinary Internal Medicine. ,vol. 21, pp. 149- 156 ,(2007) , 10.1892/0891-6640(2007)21[149:EOGAEF]2.0.CO;2
JW Hotchkiss, SWJ Reid, RM Christley, None, A survey of horse owners in Great Britain regarding horses in their care. Part 2: Risk factors for recurrent airway obstruction. Equine Veterinary Journal. ,vol. 39, pp. 301- 308 ,(2007) , 10.2746/042516407X180129
ELIANE MARTI, H. GERBER, G. ESSICH, J. OULEHLA, S. LAZARY, The genetic basis of equine allergic diseases. 1. Chronic hypersensitivity bronchitis. Equine Veterinary Journal. ,vol. 23, pp. 457- 460 ,(1991) , 10.1111/J.2042-3306.1991.TB03761.X
June E. Swinburne, Helen Bogle, Jolanta Klukowska-Rötzler, Michaela Drögemüller, Tosso Leeb, Elizabeth Temperton, Gaudenz Dolf, Vincent Gerber, A whole-genome scan for recurrent airway obstruction in Warmblood sport horses indicates two positional candidate regions. Mammalian Genome. ,vol. 20, pp. 504- 515 ,(2009) , 10.1007/S00335-009-9214-5
N.E. Robinson, F.J. Derksen, M.A. Olszewski, V.A. Buechner-Maxwell, The pathogenesis of chronic obstructivepulmonary disease of horses British Veterinary Journal. ,vol. 152, pp. 283- 306 ,(1996) , 10.1016/S0007-1935(96)80101-1
P Whittaker, Genes for asthma: much ado about nothing? Current Opinion in Pharmacology. ,vol. 3, pp. 212- 219 ,(2003) , 10.1016/S1471-4892(03)00035-3
G. H. Koppelman, G. J. te Meerman, D. S. Postma, Genetic testing for asthma European Respiratory Journal. ,vol. 32, pp. 775- 782 ,(2008) , 10.1183/09031936.00093608