摘要: A flexible and modular peptide modeling set was designed using freely available software tools. The consists of space-filling models all 20 naturally occurring amino acid side chains a kit for constructing peptides employing C-alpha carbons amide bond groups. Connectors that allow free rotation about phi psi angles on the peptide, together with explicit representation backbone hydrogen donor acceptors allows construction wide range protein secondary structure motifs. chain highlight steric, acid-base, polarity these These were printed relatively affordable commercially fused filament fabrication printers minimal postprinting processing. Use in student group activities focused acids structural features is described. © 2019 International Union Biochemistry Molecular Biology, 47(4):432-437, 2019.
sci-hub.se 参考文章(15)
Jennifer Stone-Sundberg, Werner Kaminsky, Trevor Snyder, Peter Moeck, 3D Printed Models of Small and Large Molecules, Structures and Morphologies of Crystals, as well as Their Anisotropic Physical Properties Crystal Research and Technology. ,vol. 50, pp. 432- 441 ,(2015) , 10.1002/CRAT.201400469
Tim Herman, Jennifer Morris, Shannon Colton, Ann Batiza, Michael Patrick, Margaret Franzen, David S. Goodsell, Tactile teaching: Exploring protein structure/function using physical models*. Biochemistry and Molecular Biology Education. ,vol. 34, pp. 247- 254 ,(2006) , 10.1002/BMB.2006.494034042649
P. Chakraborty, R. N. Zuckermann, Coarse-grained, foldable, physical model of the polypeptide chain. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 13368- 13373 ,(2013) , 10.1073/PNAS.1305741110
Karnyupha Jittivadhna, Pintip Ruenwongsa, Bhinyo Panijpan, Beyond textbook illustrations: Hand‐held models of ordered DNA and protein structures as 3D supplements to enhance student learning of helical biopolymers Biochemistry and Molecular Biology Education. ,vol. 38, pp. 359- 364 ,(2010) , 10.1002/BMB.20427
Jacqueline R. Roberts, Eric Hagedorn, Paul Dillenburg, Michael Patrick, Timothy Herman, Physical models enhance molecular three-dimensional literacy in an introductory biochemistry course* Biochemistry and Molecular Biology Education. ,vol. 33, pp. 105- 110 ,(2006) , 10.1002/BMB.2005.494033022426
Christopher J. Halkides, Using Molecular Models To Show Steric Clash in Peptides: An Illustration of Two Disallowed Regions in the Ramachandran Diagram Journal of Chemical Education. ,vol. 90, pp. 760- 762 ,(2013) , 10.1021/ED3001528
Michelle A. Harris, Ronald F. Peck, Shannon Colton, Jennifer Morris, Elias Chaibub Neto, Julie Kallio, A Combination of Hand-held Models and Computer Imaging Programs Helps Students Answer Oral Questions about Molecular Structure and Function: A Controlled Investigation of Student Learning CBE- Life Sciences Education. ,vol. 8, pp. 29- 43 ,(2009) , 10.1187/CBE.08-07-0039
Eric F. Pettersen, Thomas D. Goddard, Conrad C. Huang, Gregory S. Couch, Daniel M. Greenblatt, Elaine C. Meng, Thomas E. Ferrin, UCSF Chimera--a visualization system for exploratory research and analysis. Journal of Computational Chemistry. ,vol. 25, pp. 1605- 1612 ,(2004) , 10.1002/JCC.20084
Sachel M. Villafañe, Jennifer Loertscher, Vicky Minderhout, Jennifer E. Lewis, Uncovering students' incorrect ideas about foundational concepts for biochemistry Chemistry Education Research and Practice. ,vol. 12, pp. 210- 218 ,(2011) , 10.1039/C1RP90026A
Sergio Rossi, Maurizio Benaglia, Davide Brenna, Riccardo Porta, Manuel Orlandi, Three Dimensional (3D) Printing : a Straightforward, User-Friendly Protocol To Convert Virtual Chemical Models to Real-Life Objects Journal of Chemical Education. ,vol. 92, pp. 1398- 1401 ,(2015) , 10.1021/ACS.JCHEMED.5B00168