Expression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance.
作者： Robert G. Lingeman , Robert J. Hickey , Linda H. Malkas
DOI: 10.1007/S00280-014-2574-X
关键词:
摘要: An 8 amino acid peptide sequence derived from proliferating cell nuclear antigen (PCNA) has been shown to effectively kill several breast cancer and neuroblastoma lines when added exogenously cultures. In this study, the expression of (caPeptide) was placed under control a tetracycline responsive promoter in MDA-MB-231 cells. Endogenous resulted an increase genomic DNA damage. CaPeptide induction combined with treatment sublethal doses cisplatin marked death cisplatin-resistant line. found interact POLD3, one subunits polymerase delta necessary for binding PCNA. These results suggest important line inquiry into possible role that caPeptide might play reversal resistance other cancers. This is particular interest those cancers where first chemotherapy acquisition common malady.
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