Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism.

摘要: The Indian traditional system of medicine prescribed plant therapies for diseases including diabetes mellitus called madhumeh in Sanskrit. One such mentioned Ayurveda is Pterocarpus marsupium (PM). In the present study, aqueous extract PM (1 g/kg PO) was assessed its effect on glycogen levels insulin dependent (skeletal muscle and liver), insulin-independent tissues (kidneys brain) enzymes as glucokinase (GK), hexokinase (HK), phosphofructokinase (PFK). Administration led to decrease blood glucose by 38 60% 15th 30th day experiment. Liver 2-kidney weight expressed percentage body-weight significantly increased diabetics (p < 0.0005) vs. normal controls this alteration renal but not liver normalized feeding extract. Renal content over 10 fold while hepatic skeletal decreased 75 68% diabetic these partly prevented PM. Activity HK, GK PFK 35, 50 completely corrected only HK GK.