Clinically Significant Interactions with Benzodiazepines

摘要: Benzodiazepines are a class of lipophilic compounds used for variety indications including anxiety disorders, insomnia, epilepsy, musculoskeletal and as sedatives during surgery. The chemical nucleus each benzodiazepine well their pharmacodynamic activity is identical. However, alterations to this basic structure lead numerous benzodiazepines with different pharmacokinetic properties lipid solubility resulting in agents differing rates elimination, concentrations, volumes distribution, potencies. In chapter we will review the varied kinetics available discuss metabolic pathways leading excretion these medications. This includes enzymes (Phase I Phase II) responsible metabolism parent compound intermediates. We also pharmacologic intermediate metabolites. Furthermore identify interactions including: drug-drug interactions, P-gylcoprotein protein-binding food/herbal interactions. Other factors that may require dosing such weight, sex, age, smoking status, genetic polymorphisms, similarly be discussed. Finally clinical monitoring required individuals being prescribed respiratory depression, sedation, withdrawal. goal give reader background should considered when choosing or practice.