Plasma Cell Neoplasms: MGUS and Myeloma

摘要: Neoplasms of plasma cells are a group diseases characterized by the presence clonal in bone marrow (BM). These entities placed into particular diagnostic category based on their overall clinical, laboratory, and pathological features. They range from relatively common, asymptomatic disorder called monoclonal gammopathy undetermined significance to progressive typically incurable disease multiple myeloma (MM). Neoplastic share many same morphological immunophenotypic features normal cells. also retain functions activities including production immunoglobulin (Ig) accumulation BM. However, cell neoplasms, derangement these leads typical signs symptoms disease. This includes cytopenias BM failure, lytic skeletal lesions due alterations microenvironment, Ig blood urine, and, related this, renal insufficiency glomerular deposition. Over last decade, there have been major advances treatment MM introduction whole new classes drugs such as proteasome inhibitors thalidomide-based immunomodulatory drugs. As such, patients now options, whereas formerly, transplant may only hope. There understanding underlying pathophysiology genetics, this has enabled better classification prognostication patients. article will review clinical features, criteria, with neoplasms.