A long-term study of prognosis in monoclonal gammopathy of undetermined significance.
作者： Robert A Kyle , Terry M Therneau , S Vincent Rajkumar , Janice R Offord , Dirk R Larson
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摘要: Background A monoclonal gammopathy of undetermined significance (MGUS) occurs in up to 2 percent persons 50 years age or older. Reliable predictors progression have not been identified, and information on prognosis is limited. Methods We identified 1384 patients residing southeastern Minnesota whom MGUS was diagnosed at the Mayo Clinic from 1960 through 1994. The primary end point multiple myeloma another plasma-cell cancer. Results During 11,009 person-years follow-up, progressed 115 myeloma, IgM lymphoma, amyloidosis, macroglobulinemia, chronic lymphocytic leukemia, plasmacytoma (relative risk progression, 25.0, 2.4, 8.4, 46.0, 0.9, 8.5, respectively). overall relative 7.3 these as compared with white population Iowa Surveillance, Epidemiology, End program. In 32 additional patients, protein concentration increased more than 3...
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