Understanding the Role of Natural Killer T Cells in Hematologic Malignancies: Progress and Challenges
作者： Natalia Neparidze , Madhav V. Dhodapkar
DOI: 10.1007/978-1-4614-0613-6_9
关键词:
摘要: Natural Killer T (NKT) cells have emerged as important effector in tumor immunity. Hematologic malignancies are particularly attractive targets of NKT mediated anti-tumor effects most hematologic tumors express CD1d. Patients with several been reported to carry quantitative or qualitative defects cells. Preliminary clinical studies suggest the capacity alpha-galactosylceramide (α-GalCer) loaded dendritic stimulate vivo. However harnessing clinic will also require attention reversing function Improved understanding cross-talk between type I and II cells, well nature naturally occurring CD1d binding ligands these patients is needed optimally target malignancies.
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