Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation
作者： Jin S Im , Pooja Arora , Gabriel Bricard , Alberto Molano , Manjunatha M Venkataswamy
DOI: 10.1016/J.IMMUNI.2009.03.022
关键词:
摘要: CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability secrete both T helper 1 (Th1) cell- Th2 cell-type cytokines. We analyzed presentation NKT cell activating α galactosylceramide (αGalCer) analogs give predominantly cytokine responses determine how ligand structure controls the outcome activation. Using monoclonal antibody specific for αGalCer-CD1d complexes visualize quantitate glycolipid presentation, we found cytokine-biasing ligands were characterized by rapid direct loading cell-surface CD1d proteins. Complexes formed association these αGalCer with showed distinctive exclusion from ganglioside-enriched, detergent-resistant plasma membrane microdomains antigen-presenting cells. These findings help explain subtle alterations in can control balance proinflammatory anti-inflammatory
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