Bioavailability study of tolbutamide β-cyclodextrin inclusion compounds, solid dispersions and bulk powder

摘要: Abstract Tolbutamide PEG 6000 solid dispersions as well tolbutamide β-cyclodextrin complexes were prepared with a view to increasing the bioavailability of this poorly soluble drug. Absolute and relative bioavailabilities determined by comparison administration commercial solution The study was carried out in rabbits (n = 5 per dosage form). aqueous (Dolipol®) administered either intravenously (10 mg/kg) or orally (20 mg/kg). Bulk powder, comelt, coprecipitate complex at dose 20 mg/kg. Plasma concentrations measured an HPLC method. Our results indicate that absorption is not increased bulk powder However, there are obvious differences kinetics absorption: indeed, absorbed rapidly from powder. process much slower for other forms. Finally, even if quantitative part modified, complexation cyclodextrins could be interesting order increase kinetic drugs.