Oral bioavailability of naproxen-β-cyclodextrin inclusion compound

摘要: Abstract An inclusion complex between naproxen and β-cyclodextrin was prepared by the freeze-drying method. Dissolution profiles in a pH 1.2 medium (gastric juice) of naproxen, freeze-dried physical mixture 1:1 1:3 complexes demonstrated faster dissolution rate complex. After 5 min amount drug dissolved around 5% for drug, 12% 11% 61 99% complexes, respectively. The bioavailability administered as its with has been evaluated using new HPLC method determining glucuronide conjugate urine. Renal excretion levels after oral administrations β-cyclodextrin, measured this method, show no statistical differences, indicating that three formulations assayed are bioequivalent.