Copolymeric micelles as efficient inert nanocarrier for hypericin in the photodynamic inactivation of Candida species.
作者： Isis RG Capoci , Franciele AV Rodrigues-Vendramini , Neli Pieralisi , Gabriel B Cesar , Renato S Gonçalves
关键词:
摘要: Aim: To evaluate the efficacy of photodynamic inactivation (PDI) mediated by hypericin encapsulated in P-123 copolymeric micelles (P123-Hyp) alone and combination with fluconazole (FLU) against planktonic cells biofilm formation Candida species Materials & methods: PDI was performed using P123-Hyp an LED device irradiance 3.0 mW/cm2 . Results: Most isolates (70%) were completely inhibited concentrations up to 2.0 μmol/l HYP light fluence 16.2 J/cm2. FLU-resistant strains had synergic effect P123-HYP-PDI FLU. The all species, additional changes morphology observed scanning electron microscopy. Conclusion: P123-Hyp-PDI is a promising option treat fungal infections medical devices prevent spread.
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