Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1.

摘要: Recent studies have demonstrated a crucial role for TNF during inflammatory granuloma formation. In addition, has been shown to up-regulate adhesion molecules that participate in cellular recruitment and lymphocyte activation. the present study, we examined mechanism of activation Schistosoma mansoni egg formation its relationship expression ICAM-1. Our initial showed high affinity human soluble TNFR coupled Fc portion an Ig (sTNFR:Fc construct) could effectively diminish vivo. We also assessed increased ICAM-1, contribution development, with lesion Increased steady state ICAM-1 mRNA was observed primary granulomas when compared normal lung foreign body (Sephadex bead) granulomas, which suggests Ag-induced Subsequent sTNFR:Fc treatment down-regulated expression, thus suggesting one involvement through induction Anti-ICAM-1 decreased Ag-specific T cell proliferation vitro. passive immunization mice anti-ICAM-1 mAb resulted attenuation development as control Ab-treated group. The proliferative response Ag significantly reduced ex vivo experiments used spleen cells from treated mice. These data demonstrate both suggest is TNF-induced expression.