Cellular Mechanism of Intraabdominal Abscess Formation by Bacteroides fragilis
作者： Andrew B. Onderdonk , Frank C. Gibson , Dennis L. Kasper , Arthur O. Tzianabos
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摘要: We investigated the cellular mechanism by which Bacteroides fragilis promotes development of intraabdominal abscesses in experimental models sepsis. B. fragilis, as well purified capsular polysaccharide complex (CPC) from this organism, adhered to primary murine mesothelial cells (MMCs) vitro. The binding CPC peritoneal macrophage stimulated TNF-alpha production, when transferred monolayers MMCs elicited significant ICAM-1 expression these cells. This response resulted enhanced polymorphonuclear leukocyte attachment that could be inhibited Abs specific for or ICAM-1. Mice treated with TNF-alpha- ICAM-1-specific failed develop following challenge CPC. These results illustrated role promoting adhesion wall and coordinating events leading associated
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