作者: Kerstin Schirrmann , Michael Mertens , Ulrich Kertzscher , Klaus Affeld , Wolfgang M. Kuebler
DOI: 10.1007/978-3-642-20326-8_3
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摘要: Depending on the applied ventilation strategy, mechanical leads to alveolar epithelial and capillary endothelial damage. Protective ventilatory approaches try minimize this biotrauma while still ensuring sufficient gas exchange. However, optimization of strategies is hampered by lack insights into cellular molecular mechanisms underlying ventilator-induced lung injury, morphological biomechanical information pertinent development suitable computational experimental models for ventilation-dependent biofluid mechanics [13, 15, 30].