Automodulation of genes: a proposed mechanism for persisting effects of drugs and hormones in mammals.

摘要: We propose that hormone receptors are encoded by specially organized genetic elements have the capacity to manipulate their own structure with enzymes in controlled ways. An automodulating element codes for a cell surface receptor protein. When this detector molecule is stimulated its ligand (either natural or drug analog), signal transmitted back nucleus activate an enzyme pathway which alters of element. In particular, DNA alteration changes expression on cell, either qualitatively quantitatively, and hence sensitivity future stimulation. Thus, drugs can permanently change phenotype. It suggested further automodulation also occurs germ-line cells allowing effects exposure carry over following generations as trait.