Laparoscopic kidney orthotopic transplant: preclinical study in the pig model.

摘要: Background. Laparoscopic surgery has rapidly expanded in clinical practice replacing conventional open over the last three decades. donor nephrectomy been favored due to its multiple benefits. The aim of this study was explore safety and feasibility kidney transplantation by a laparoscopic technique pig model. Materials methods. approved university animal ethics committee. Eight female pigs (Sus Scrofra, weighing 45‐50 kg) were divided into 2 groups: group I included 4 animals that underwent orthotopic on left side. right remained functional situ. recovered observed for 1 week. In hosts II With simultaneous clipping ureter. After recovery, weeks. A laparotomy examination performed prior euthanasia. Results. All survived showed normal graft perfusion with wall patent renal artery vein as well satisfactory urine output upon transection ureter 3 hosts. Renal stenosis occurred one pig. Immediate function achieved pigs. fourth died following extubation laryngospasm despite graft. average creatinine levels 195.5 mol/L day 3; 224.5 at week 1; 127 2; 182.7 umol/L 154.7 4. Conclusion. feasible safe model immediate function. This will provide further evidence support application human transplant.