Biomimetic fabrication of alginate/CaCO3 hybrid beads for dual-responsive drug delivery under compressed CO2
作者： Jun Shi , Zhengzheng Zhang , Gefei Li , Shaokui Cao
DOI: 10.1039/C1JM11838B
关键词:
摘要: Alginate/CaCO3 hybrid beads with pH- and thermal-responsive drug release properties were prepared under compressed CO2 using aliphatic poly(urethane-amine)s (PU) as the component. Polyacrylic acid (PAA) was used a crystal growth additive to control structure of beads. The characterized by scanning electron microscopy, X-ray powder diffraction thermogravimetric analysis. interaction between PAA PU contributed formation alginate compact CaCO3 shell. Indomethacin behaviour found be thermal-responsive. profiles sustained microparticles, indicating that shell could hinder permeability encapsulated reduce effectively. results suggest can “smart” polysaccharide materials for dual-responsive delivery.
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