Long-term follow-up of peptidergic and nonpeptidergic reinnervation of the epidermis following sciatic nerve reconstruction in rats.

作者: Shoista Kambiz , Liron S. Duraku , Martijn Baas , Tim H. J. Nijhuis , Saniye G. Cosgun

DOI: 10.3171/2014.12.JNS141075

关键词:

摘要: OBJECT Peripheral nerve injuries are a commonly encountered clinical problem and often result in long-term functional deficits. The current gold standard for transected nerves is an end-to-end reconstruction, which results the intermittent appearance of neuropathic pain. METHODS To improve our understanding relation between this type reconstruction pain, authors immediately reconstructed sciatic rats. effect procedure on as measured by thermal mechanical hypersensitivity at 4 different time points (5, 10, 20, 30 weeks), was related to density peptidergic nonpeptidergic fiber innervation glabrous skin rats' hind paws. RESULTS Thermal occurring 20 weeks after accompanied significant increase epidermal fibers. However, lesion-induced reduction fibers remained decreased all ex...

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