Effects of Age on Thermal Sensitivity in the Rat
作者： R. P. Yezierski , C. D. King , D. Morgan , C. S. Carter , C. J. Vierck
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摘要: Age-dependent changes in thermal sensitivity were evaluated with reflex- and operant-based assessment strategies animals ranging age from 8 to 32 months. The impact of inflammatory injury on was also determined different ages. results showed that operant measures escape behavior are needed demonstrate significant across the life span female Long-Evans rats. Increased both heat (44.5°C) cold (1.5°C–15°C) observed for older animals, a greater relative increase cold. Physical performance deficits demonstrated aging but not associated responding. Reflex responding stimulation impaired influenced by physical disabilities. affected increasing age. Inflammation induced formalin injections dorsal hindpaw increased significantly more than their younger counterparts.
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