Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain
作者： Yui Mano , Ryuta Saito , Yoichi Haga , Tadao Matsunaga , Rong Zhang
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摘要: OBJECT Convection-enhanced delivery (CED) is an effective drug method that delivers high concentrations of drugs directly into the targeted lesion beyond blood-brain barrier. However, distribution attained using CED has not satisfactorily covered entire in tumors such as glioma. Recently, efficacy ultrasound assistance was reported for various applications. The authors developed a new ultrasound-facilitated (UFD) system enables application at infusion site. purpose this study to demonstrate UFD and examine profiles. METHODS fabricated steel bar-based device generates aqueous from one end bar. volume (Vd) after 10 ml 2% Evans blue dye (EBD) rodent brain tested with different frequencies applied voltages: 252 kHz/30 V; kHz/6...
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