Pulsed ultrasound expands the extracellular and perivascular spaces of the brain.
作者： David S. Hersh , Ben A. Nguyen , Jimena G. Dancy , Arjun R. Adapa , Jeffrey A. Winkles
DOI: 10.1016/J.BRAINRES.2016.06.040
关键词:
摘要: Diffusion within the extracellular and perivascular spaces of the brain plays an important role in biological processes, therapeutic delivery, and clearance mechanisms within the central nervous system. Recently, ultrasound has been used to enhance the dispersion of locally administered molecules and particles within the brain, but ultrasound-mediated effects on the brain parenchyma remain poorly understood. We combined an electron microscopy-based ultrastructural analysis with high-resolution tracking of non-adhesive nanoparticles in …
sci-hub.se 参考文章(48)
Langer R, Drug delivery and targeting Nature. ,vol. 392, pp. 5- 10 ,(1998)
Ferenc A. Jolesz, Nathan J. McDannold, Magnetic Resonance–Guided Focused Ultrasound: A New Technology for Clinical Neurosciences Neurologic Clinics. ,vol. 32, pp. 253- 269 ,(2014) , 10.1016/J.NCL.2013.07.008
George K. Lewis, Zachary R. Schulz, Susan C. Pannullo, Teresa L. Southard, William L. Olbricht, Ultrasound-assisted convection-enhanced delivery to the brain in vivo with a novel transducer cannula assembly: Laboratory investigation Journal of Neurosurgery. ,vol. 117, pp. 1128- 1140 ,(2012) , 10.3171/2012.7.JNS11144
Andrew R. Mendelsohn, James W. Larrick, Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases. Rejuvenation Research. ,vol. 16, pp. 518- 523 ,(2013) , 10.1089/REJ.2013.1530
Jenna M. Tarasoff-Conway, Roxana O. Carare, Ricardo S. Osorio, Lidia Glodzik, Tracy Butler, Els Fieremans, Leon Axel, Henry Rusinek, Charles Nicholson, Berislav V. Zlokovic, Blas Frangione, Kaj Blennow, Joël Ménard, Henrik Zetterberg, Thomas Wisniewski, Mony J. de Leon, Clearance systems in the brain—implications for Alzheimer disease Nature Reviews Neurology. ,vol. 11, pp. 457- 470 ,(2015) , 10.1038/NRNEUROL.2015.119
Matthew E. Downs, Amanda Buch, Maria Eleni Karakatsani, Elisa E. Konofagou, Vincent P. Ferrera, Blood-Brain Barrier Opening in Behaving Non-Human Primates via Focused Ultrasound with Systemically Administered Microbubbles. Scientific Reports. ,vol. 5, pp. 15076- 15076 ,(2015) , 10.1038/SREP15076
Kuo-Chen Wei, Po-Chun Chu, Hay-Yan Jack Wang, Chiung-Yin Huang, Pin-Yuan Chen, Hong-Chieh Tsai, Yu-Jen Lu, Pei-Yun Lee, I-Chou Tseng, Li-Ying Feng, Peng-Wei Hsu, Tzu-Chen Yen, Hao-Li Liu, Focused Ultrasound-Induced Blood–Brain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study PLoS ONE. ,vol. 8, pp. e58995- ,(2013) , 10.1371/JOURNAL.PONE.0058995
Craig S. Schneider, Jimena G. Perez, Emily Cheng, Clark Zhang, Panagiotis Mastorakos, Justin Hanes, Jeffrey A. Winkles, Graeme F. Woodworth, Anthony J. Kim, Minimizing the Non-specific Binding of Nanoparticles to the Brain Enables Active Targeting of Fn14-positive Glioblastoma Cells Biomaterials. ,vol. 42, pp. 42- 51 ,(2015) , 10.1016/J.BIOMATERIALS.2014.11.054
Robert G. Thorne, Sabina Hrabětová, Charles Nicholson, Diffusion of Epidermal Growth Factor in Rat Brain Extracellular Space Measured by Integrative Optical Imaging Journal of Neurophysiology. ,vol. 92, pp. 3471- 3481 ,(2004) , 10.1152/JN.00352.2004
Elizabeth Nance, Kelsie Timbie, G. Wilson Miller, Ji Song, Cameron Louttit, Alexander L. Klibanov, Ting-Yu Shih, Ganesh Swaminathan, Rafael J. Tamargo, Graeme F. Woodworth, Justin Hanes, Richard J. Price, Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound. Journal of Controlled Release. ,vol. 189, pp. 123- 132 ,(2014) , 10.1016/J.JCONREL.2014.06.031