miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6
作者： Xiaolan Zhu , Yuefeng Li , Huiling Shen , Hao Li , Lulu Long
DOI: 10.1016/J.FEBSLET.2012.11.004
关键词:
摘要: MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 pathogenesis lung cancer. The downregulation cancer cells could be rescued following inhibition DNA methylation. Ectopic expression significantly downregulated Cdc42, Cdk6 and induced G1 cell cycle arrest, leading to a significant decrease growth vivo vitro. Further, both Cdc42 were confirmed targets miR-137.
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