Activation of CD95 (APO‐1/Fas) signaling by ceramide mediates cancer therapy‐induced apoptosis
作者： Ingrid Herr , Dagmar Wilhelm , Thomas Böhler , Peter Angel , Klaus‐Michael Debatin
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摘要: We report here that anticancer drugs such as doxorubicin lead to induction of the CD95 (APO-1/Fas) system apoptosis and cellular stress pathway which includes JNK/SAPKs. Ceramide, accumulates in response different types chemo- radiotherapy, strongly induced expression CD95-L, cleavage caspases apoptosis. Antisense CD95-L well dominant-negative FADD inhibited ceramide- stress-induced Fibroblasts from type A Niemann-Pick patients (NPA), genetically deficient ceramide synthesis, failed up-regulate undergo after gamma-irradiation or treatment. In contrast, JNK/SAPK activity was still inducible by NPA cells, suggesting activation JNK/SAPKs alone is not sufficient for fibroblasts were restorable exogenously added ceramide. addition, triggering with an agonistic antibody. These data demonstrate links responses
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