Dietary Fats, Prostanoids and Arterial Thrombosis

摘要: 1. Arterial Thrombosis, Platelets and Atherogenesis.- 1.1. Pathology of arterial thrombosis.- 1.1.1. Pathogenesis 1.1.2. Thrombotic ischemia in disease.- 1.1.3. Thrombosis the coronary circulation.- 1.1.4. thromboembolism microembolism.- 1.2. atherogenesis.- 1.2.1. Organization metamorphosis thrombi.- 1.2.2. Progressive thrombosis atherosclerosis.- 1.2.3. Significance plaque development.- 1.2.4. Onset plaques by 1.2.5. Regression atherosclerosis relation to 1.3. The platelet-derived growth factor 1.3.1. concept.- 1.3.2. Experimental support.- 1.3.3. Comment.- 2. Biochemical Physiology Dietary Fats.- 2.1. Structure nomenclature fatty acids.- 2.2. Fatty acids synthesis.- 2.2.1. Chain elongation.- 2.2.2. Desaturation.- 2.3. Essential 2.4. acid degradation.- 2.5. derivatives.- 2.5.1. Triglycerides.- 2.5.2. Phospholipids.- 2.5.3. Cholesterol esters.- 2.6. Fat absorption.- 2.7. Plasmatic transport 2.8. Functions 2.8.1. Function biomembranes.- 2.8.2. as prostanoid precursors.- 2.8.3. Some other functions 2.9. Lipid metabolism platelets.- 3. Role Prostanoids Thromboregulation.- 3.1. Introduction.- 3.2. Platelet prostaglandins thromboxanes.- 3.3. Vascular prostaglandins.- 3.4. Prostanoid biosynthesis metabolism.- 3.4.1. prostanoids.- 3.4.2. 3.5. Interaction between platelet vascular 3.6. Functional significance prostanoids haemostasis 3.6.1. TxA2, aggregation ADP release.- 3.6.2. TxA2 primary haemostasis.- 3.6.3. role 3.6.4. thromboxane-prostacyclin balance.- 3.7. mechanisms action.- 3.8. 1- 3-series.- 4. Effect Type Amount Fats on Thrombus Formation.- 4.1. 4.2. fats thrombosis: a literature survey.- 4.3. New experimental model rats.- 4.4. Relationship dietary composition tendency 4.4.1. increasing amounts sunflowerseed oil thrombus formation.- 4.4.2. Comparison effect different oils formation 4.4.2.1. composition.- 4.4.2.2. function amount absorbed 4.4.3. antithrombotic oleic linoleic 4.4.4. Further evidence for prothrombotic saturated 4.4.5. cis trans 4.5. Summary.- 5. Location 5.1. 5.2. (SO) hydrogenated coconut (HCO) blood coagulation.- 5.2.1. Whole clotting time.- 5.2.2. Plasma recalcification time (PCT).- 5.2.3. Activated partial thromboplastin (APTT).- 5.2.4. Prothrombin (PT).- 5.2.5. 3 (PF 3).- 5.2.6. Vessel wall induced clotting.- 5.3. fat type aggregability.- 5.3.1. aggregation: 5.3.1.1. single dose.- 5.3.1.2. prolonged feeding.- 5.3.1.3. Conclusion.- 5.3.2. Investigations into vitro.- 5.3.3. circulating blood.- 5.3.3.1. Method measure rat 5.3.3.2. ADP-induced rats fed fats.- 5.3.3.3. Spontaneous aggregation.- 5.4. Possible which affect 5.5. 6. Effects Thrombogenesis.- 6.1. 6.2. essential deficiency.- 6.2.1. EFA-deficiency 6.2.2. EFA-deficiency.- 6.2.2.1. adhesion.- 6.2.2.2. shape change.- 6.2.2.3. 6.2.3. coagulation 3.- 6.2.4. Discrimination prostanoid-dependent prostanoid-independent EFA thrombogenesis.- 6.2.5. 6.3. 6.4. General summary.- 7. Fish Oil Feeding Blood Coagulation.- 7.1. 7.2. fish 7.2.1. cod-liver with oil.- 7.2.2. two oils.- 7.2.3. low-cholesterol 7.2.4. Discussion.- 7.3. Bleeding time: comparison 7.4. 7.4.1. 7.4.2. flowing 7.5. feeding some parameters.- 7.5.1. Vesselwall 7.5.2. 7.5.3. 7.5.4. Fibrinogen.- 7.5.5. Antithrombin III.- 7.5.6. Factor VII.- 7.5.7. 7.6. thromboxane production prostacyclin-like material.- 7.6.1. MDA- PGI-formation.- 7.6.2. Dose-response 7.6.3. level 6-keto-PGF1? 7.6.4. 7.7. 7.7.1. Conversion arachidonic (AA) timnodonic (TA) cyclo-oxygenase lipoxygenase.- 7.7.1.1. exogenous 7.7.1.2. endogenous AA TA activated 7.7.2. Prostacyclin- PGI3-formation tissue containing diet.- 7.7.3. 7.8. discussion.- 7.9. 8. Type, Acid Composition Eicosanoid Formation Platelets.- 8.1. 8.2. procedure.- 8.3. HHT HETE collagen-activated 8.3.1. Collagen-induced 8.3.2. production.- 8.3.3. 8.3.4. 8.3.5. collagen-induced 8.4. phospholipid analysis.- 8.4.1. content.- 8.4.2. class distribution.- 8.4.3. phospholipids.- 8.5. content phospholipids 8.5.1. Absolute 8.5.2. Relative 8.5.3. 8.6. consequences lipid profile membrane fluidity.- 8.6.1. Unsaturation index.- 8.6.2. Saturation 8.6.3. Cholesterol-phospholipid ratio.- 8.6.4. 8.7. 9. Linoleic Man.- 9.1. 9.2. Methods.- 9.2.1. groups diets.- 9.2.2. Filtragometer (R), device venous 9.2.3. 9.3. Results.- 9.4. 9.5. long-term thromboprotective acid.- 9.5.1. Modulation diet prefeeding an 9.5.2. possible adipose linoleate thromboprotection. A hypothesis..- 9.6. lowers aggregability tendency.- 9.7. 10. Summary Concluding Remarks.- References.