Pd PEPPSI‐IPr‐Mediated Reactions in Metal‐Coated Capillaries Under MACOS: The Synthesis of Indoles by Sequential Aryl Amination/ Heck Coupling
作者： Gjergji Shore , Sylvie Morin , Debasis Mallik , Michael G. Organ
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摘要: A method has been devised for the microwave-assisted, continuous-flow preparation of indole alkaloids by a two-step aryl amination/cross-coupling sequence bromoalkenes and 2-bromoanilines. This process requires both presence metal-lined flow tube (a 1180 micron capillary) Pd PEPPSI-IPr catalyst; without either, catalyst or film, there is zero turnover this catalytic process. silver film shown to provide some conversion (48-62 %), but optimal results (quantitative) across variety bromoanilines were achieved using highly porous palladium film. Possible roles are considered, as interplay
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