Perinatal Taurine Exposure Programs Patterns of Autonomic Nerve Activity Responses to Tooth Pulp Stimulation in Adult Male Rats

摘要: Perinatal taurine excess or deficiency influences adult health and disease, especially relative to the autonomic nervous system. This study tests hypothesis that perinatal exposure system control of arterial pressure in response acute electrical tooth pulp stimulation. Female Sprague–Dawley rats were fed with normal rat chow 3% β-alanine (taurine depletion, TD), supplementation, TS), water alone (control, C) from conception weaning. Their male offspring tap throughout experiment. At 8–10 weeks age, blood chemistry, pressure, heart rate, renal sympathetic nerve activity measured anesthetized rats. Age, body weight, mean plasma electrolytes, urea nitrogen, creatinine, cortisol not significantly different among three groups. Before stimulation, low- (0.3–0.5 Hz) high-frequency (0.5–4.0 power spectral densities groups while decreased TD compared Tooth stimulation did change nerve, 0.3–4.0 Hz spectrum firing rate any group. In contrast, imbalance disturbed very-low-frequency both (below 0.1 Hz), before after The TS most sensitive ganglionic blockade central adrenergic inhibition, those peripheral inhibition. present data indicate can lead aberrant responses